What Are the Health Benefits of Panax Ginseng?

Panax ginseng, a type of ginseng commonly used in herbal medicine, has been touted for several health benefits, including in cholesterol, inflammation, diabetes, and other uses. However, there is not enough high-quality research to confirm the benefits of this herb.

The ginseng plant grows in the mountains of East Asia, where its roots are harvested into ginseng that is consumed—often in teas and supplements.

This article takes a closer look at Panax ginseng’s benefits, its researched uses, potential side effects, and what to look for when buying supplements.

Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. When possible, choose a supplement tested by a trusted third party, such as USP, ConsumerLab, or NSF. 
However, even if supplements are third-party tested, that doesn’t mean they are necessarily safe for all or effective in general. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications.

Supplement Facts

  • Active ingredient(s): Ginsenosides
  • Alternate name(s): Panax ginseng, Asian ginseng, Chinese ginseng, Korean ginseng, red ginseng, white ginseng (not to be confused with Siberian ginseng, American ginseng, pseudoginseng, or black ginseng, all of which come from a different plant)
  • Suggested dose: No standard dose suggested
  • Safety considerations: Relatively safe for short-term use but not recommended in certain groups—it also interacts with several medications

Purported Uses of Panax Ginseng

Panax ginseng is often promoted as a general tonic to improve well-being or cholesterol health. It’s also sometimes taken for inflammatory conditions or to help lower blood sugar in those with diabetes.

Though touted to help with several health conditions, there is not enough high-quality research to provide clear recommendations for Panax ginseng’s use.

Diabetes

Panax ginseng may have a glucose-lowering effect and has been studied as an add-on therapy in people with diabetes. Several meta-analyses and systematic reviews have evaluated studies conducted on the use of ginseng in diabetes.

One meta-analysis found that supplementing ginseng did not lower hemoglobin A1C (HbA1c) levels in people with type 2 diabetes. Ginseng did improve fasting glucose and postprandial insulin but not postprandial glucose and fasting insulin.

A systematic review and meta-analysis published in PLOS One found that ginseng, compared with a placebo, significantly reduced fasting blood glucose.

However, the overall clinical effect was modest. Blood glucose levels dropped by about 5 milligrams/deciliter and most of the individuals already had well-controlled glucose levels. This is important because a modest change may result in statistical significance, but the actual clinical significance is questionable.

In this same review, ginseng did not affect fasting plasma insulin, insulin resistance scores, or HbA1C levels.

Getting convincing evidence from a meta-analysis is challenging because study designs vary widely, including different types or forms of ginseng, doses, and study lengths.

More well-designed studies are necessary before recommending ginseng for blood sugar management.

What Is Hemoglobin A1C?

Hemoglobin A1C is a blood test for people with diabetes that tells healthcare providers how well they managed their glucose levels over the previous three months.

Cholesterol

High cholesterol levels are a risk factor for developing coronary artery disease. Some studies have shown that Panax ginseng may have a cholesterol-lowering effect.

One meta-analysis of the effects of ginseng on lipid profiles found that there was no significant overall improvement in cholesterol, triglyceride, or high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels. But a small subgroup had some significant changes when ginseng was taken at higher doses or for longer periods.

A separate meta-analysis found that Panax ginseng reduced total and LDL-cholesterol levels but did not improve HDL-cholesterol.

A systematic review of research in people with prediabetes or type 2 diabetes showed that Panax ginseng lowered total and LDL-cholesterol when the dose was at least 2 grams daily.

In another meta-analysis from Korea, Panax ginseng reduced blood pressure, total and LDL cholesterol, and triglyceride levels when compared with a placebo.

Again, further high-quality research is necessary to determine what dosage will achieve the desired effect on cholesterol levels.

Dietary supplements should only be taken in addition to (not instead of) medical standard care. If you have high cholesterol, talk to your healthcare provider about an appropriate plan that includes diet modification, physical activity, and medications.

Ginseng capsules, tincture, and powder

Verywell / Anastasia Tretiak

Inflammation

Low-grade inflammation is thought to lead to several diseases and conditions. As a result, there is a major focus on products that have anti-inflammatory effects, which may include ginseng.

A systematic review of the effects of ginseng on inflammatory markers found that ginseng may lower interleukin-6 (IL-6) and tumor necrosis factor (alpha TNF-α) but not C-reactive protein (CRP).

The researchers also mentioned some of the studies were biased. Further research is necessary to determine the dosage that will result in significant reductions of these markers.

A separate meta-analysis found that ginseng did significantly reduce CRP levels but only in individuals who already had an elevated CRP.

More clinical studies are necessary to confirm whether ginseng is an appropriate additional therapy for addressing inflammation.

Other Conditions

Although supplements can help, they are never a “cure-all” option. It is important to be wary of any supplement that claims to treat or cure a medical condition. In some cases, supplements may be touted for a health condition for which they have no benefit.

For instance, studies have found that Panax ginseng:

  • May help relieve hot flashes
  • Doesn’t boost athletic endurance
  • Has not been proven to fight cancer
  • Does not appear to prevent or treat upper respiratory infections

What Are the Side Effects of Panax Ginseng?

Ginseng use is common. It is even found in beverages, which may lead you to believe it’s completely safe. But like any herbal supplement or medication, taking it can result in unwanted effects.

The most common side effect of ginseng is insomnia. Additional reported side effects include:

  • Headaches
  • Nausea
  • Diarrhea
  • Blood pressure changes
  • Mastalgia (breast pain)
  • Vaginal bleeding

Allergic reactions, severe rash, and liver damage are less common side effects but can be serious.

Precautions

Children and pregnant or nursing people should avoid taking Panax ginseng.

If you are considering taking Panax ginseng, talk to your healthcare provider if you have:

  • High blood pressure: Panax ginseng may affect blood pressure.
  • Diabetes: Panax ginseng may lower blood sugar levels and interact with diabetes medications.
  • Blood clotting disorders: Panax ginseng can interfere with blood clotting and interact with some anticoagulant drugs.

Dosage: How Much Panax Ginseng Should I Take?

Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs.

The dosage of Panax ginseng depends on the type of ginseng, the reason for using it, and the amount of ginsenosides in the supplement.

There is no recommended standard dose of Panax ginseng. It is often taken in doses of 200 milligrams (mg) per day in studies. Some have recommended 500–2,000 mg per day if taken from the dry root.

Because dosages can vary, make sure to read the product label for instructions on how to take it. Before starting Panax ginseng, talk to a healthcare provider to determine a safe and appropriate dosage.

What Happens if I Take Too Much Panax Ginseng?

There isn’t much data on the toxicity of Panax ginseng. Toxicity isn’t likely to occur when taken in the appropriate amounts for a short time. Side effects are more likely if you take too much.

Interactions

Panax ginseng interacts with several types of medications. It is important to tell your healthcare provider all the prescription and OTC medication, herbal remedies, and supplements you take. They can help determine if it is safe to take Panax ginseng.

Potential interactions include:

  • Caffeine or stimulant drugs: The combination with ginseng may increase heart rate or blood pressure.
  • Blood thinners such as Jantoven (warfarin): Ginseng may slow blood clotting and decrease the effectiveness of certain blood thinners. If you take blood thinners, discuss Panax ginseng with your healthcare provider before starting it. They may be able to check your blood levels and adjust dosage accordingly.
  • Insulin or oral diabetes medications: Using these with ginseng may result in hypoglycemia because they help lower blood sugar levels.
  • Monoamine oxidase inhibitors (MAOI): Ginseng may increase the risk of side effects associated with MAOIs, including manic-like symptoms.
  • Diuretic Lasix (furosemide): Ginseng may reduce the effectiveness of furosemide.
  • Ginseng can increase the risk of liver toxicity if taken with certain medications, including Gleevec (imatinib) and Isentress (raltegravir).
  • Zelapar (selegiline): Panax ginseng may affect the levels of selegiline.
  • Panax ginseng can interfere with drugs processed by an enzyme called cytochrome P450 3A4 (CYP3A4).

More interactions may occur with other drugs or supplements. Before taking Panax ginseng, ask your healthcare provider or pharmacist for more information on potential interactions.

Recap

Ginseng has the potential to interact with several different types of medications. Before taking herbal supplements, ask your pharmacist or healthcare provider if ginseng is safe for you based on your current health status and medications.

Panax Ginseng capsules
Verywell / Anastasia Tretiak

How to Store Panax Ginseng

Follow manufacturer directions for the best way to store Panax ginseng. Always keep out of reach of children and pets.

Similar Supplements

There are several different types of ginseng. Some derive from different plants and may not have the same effect as Panax ginseng. Supplements can also come from root extract or root powder.

Additionally, ginseng may be classified by the following:

  • Fresh (less than 4 years old)
  • White (4–6 years old, peeled and then dried)
  • Red (more than 6 years old, steamed and then dried)

Frequently Asked Questions

  • Does Panax ginseng help with erectile dysfunction (ED)?

    A review by the Cochrane Collaboration found that ginseng “may only have trivial effects” on erectile dysfunction (ED). The authors also noted that no study has compared ginseng to common ED medications. Be sure to talk with your healthcare provider about ED treatment options.

  • Can Panax ginseng enhance cognitive function or help older adults with dementia?

    A 2014 review noted that the evidence to date suggested that while ginseng may have potential benefits, the evidence wasn't sufficient to prove benefits. The studies were short-term and had very different methodologies, making it difficult to draw firm conclusions. Nor is there high-quality research to support its use for people with dementia.

Sources of Panax Ginseng and What to Look For

Panax ginseng comes from the root of the plant in the genus Panax. It is an herbal remedy made from the plant’s root and isn’t something you typically get in your diet.

When looking for a ginseng supplement, consider the following:

  • The type of ginseng
  • Which part of the plant the ginseng came from (e.g., root)
  • Which form of ginseng is included (e.g., powder or extract)
  • The amount of ginsenosides in the supplement (the standard recommended amount of ginsenoside content in supplements is 1.5–7%)

For any supplement or herbal product, look for one that has been third-party tested. This provides some quality assurance in that the supplement contains what the label says it does and is free of harmful contaminants. Look for labels from the United States Pharmacopeia (USP), the National Science Foundation (NSF), or ConsumerLab.

Summary

Herbal remedies and alternative medicines are popular, but don’t forget that just because something is labeled “natural” doesn’t mean it’s safe. The FDA regulates dietary supplements as food items, which means they aren’t regulated as strictly as drugs are.

Ginseng is often found in herbal supplements and drinks. It is touted to help manage many health conditions, but there is not enough research to prove the efficacy of its use. When searching for products, look for supplements certified for quality by an independent third party, like the NSF, or ask your healthcare provider for a reputable brand recommendation.

Ginseng supplementation may result in some mild effects. It also interacts with several different medications. It is important to discuss herbal remedies with your healthcare provider to understand their risks versus their benefits.

23 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. National Center for Complementary and Integrative Health. Asian ginseng.

  2. Gui QF, Xu ZR, Xu KY, Yang YM. The efficacy of ginseng-related therapies in type 2 diabetes mellitus: an updated systematic review and meta-analysisMedicine (Baltimore). 2016;95(6):e2584. doi:10.1097/MD.0000000000002584

  3. Shishtar E, Sievenpiper JL, Djedovic V, et al. The effect of ginseng (the genus Panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. PLoS One. 2014;9(9):e107391. doi:10.1371/journal.pone.0107391

  4. Ziaei R, Ghavami A, Ghaedi E, et al. The efficacy of ginseng supplementation on plasma lipid concentration in adults: a systematic review and meta-analysisComplement Ther Med. 2020;48:102239. doi:10.1016/j.ctim.2019.102239

  5. Hernández-García D, Granado-Serrano AB, Martín-Gari M, Naudí A, Serrano JC. Efficacy of Panax ginseng supplementation on blood lipid profile. A meta-analysis and systematic review of clinical randomized trialsJ Ethnopharmacol. 2019;243:112090. doi:10.1016/j.jep.2019.112090

  6. Naseri K, Saadati S, Sadeghi A, et al. The efficacy of ginseng (Panax) on human prediabetes and type 2 diabetes mellitus: a systematic review and meta-analysisNutrients. 2022;14(12):2401. doi:10.3390/nu14122401

  7. Park SH, Chung S, Chung MY, et al. Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: a systematic review and meta-analysisJ Ginseng Res. 2022;46(2):188-205. doi:10.1016/j.jgr.2021.10.002

  8. Mohammadi H, Hadi A, Kord-Varkaneh H, et al. Effects of ginseng supplementation on selected markers of inflammation: a systematic review and meta-analysisPhytother Res. 2019;33(8):1991-2001. doi:10.1002/ptr.6399

  9. Saboori S, Falahi E, Rad EY, et al. Effects of ginseng on C-reactive protein level: a systematic review and meta-analysis of clinical trialsComplement Ther Med. 2019;45:98-103. doi:10.1016/j.ctim.2019.05.021

  10. Lee HW, Ang L, Lee MS. Using ginseng for menopausal women's health care: a systematic review of randomized placebo-controlled trials. Complement Ther Clin Pract. 2022;48:101615. doi:10.1016/j.ctcp.2022.101615

  11. Sellami M, Slimeni O, Pokrywka A, et al. Herbal medicine for sports: a reviewJ Int Soc Sports Nutr. 2018;15:14. doi:10.1186/s12970-018-0218-y

  12. Kim S, Kim N, Jeong J, et al. Anti-cancer effect of Panax ginseng and its metabolites: from traditional medicine to modern drug discovery. Processes. 2021;9(8):1344. doi:10.3390/pr9081344

  13. Antonelli M, Donelli D, Firenzuoli F. Ginseng integrative supplementation for seasonal acute upper respiratory infections: a systematic review and meta-analysis. Complement Ther Med. 2020;52:102457. doi:10.1016/j.ctim.2020.102457

  14. Hassen G, Belete G, Carrera KG, et al. Clinical implications of herbal supplements in conventional medical practice: a US perspective. Cureus. 2022;14(7):e26893. doi:10.7759/cureus.26893

  15. Li CT, Wang HB, Xu BJ. A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2. Pharm Biol. 2013;51(8):1077-1080. doi: 10.3109/13880209.2013.775164

  16. Malík M, Tlustoš P. Nootropic herbs, shrubs, and trees as potential cognitive enhancers. Plants (Basel). 2023;12(6):1364. doi:10.3390/plants12061364

  17. Awortwe C, Makiwane M, Reuter H, Muller C, Louw J, Rosenkranz B. Critical evaluation of causality assessment of herb-drug interactions in patients. Br J Clin Pharmacol. 2018;84(4):679-693. doi:10.1111/bcp.13490

  18. Mancuso C, Santangelo R. Panax ginseng and Panax quinquefolius: from pharmacology to toxicology. Food Chem Toxicol. 2017;107(Pt A):362-372. doi:10.1016/j.fct.2017.07.019

  19. Mohammadi S, Asghari G, Emami-Naini A, Mansourian M, Badri S. Herbal supplement use and herb-drug interactions among patients with kidney disease. J Res Pharm Pract. 2020;9(2):61-67. doi:10.4103/jrpp.JRPP_20_30

  20. Yang L, Li CL, Tsai TH. Preclinical herb-drug pharmacokinetic interaction of Panax ginseng extract and selegiline in freely moving rats. ACS Omega. 2020;5(9):4682-4688. doi:10.1021/acsomega.0c00123

  21. Lee HW, Lee MS, Kim TH, et al. Ginseng for erectile dysfunction. Cochrane Database Syst Rev. 2021;4(4):CD012654. doi:10.1002/14651858.CD012654.pub2

  22. Smith I, Williamson EM, Putnam S, Farrimond J, Whalley BJ. Effects and mechanisms of ginseng and ginsenosides on cognition. Nutr Rev. 2014;72(5):319-333. doi:10.1111/nure.12099

  23. Food and Drug Administration. Dietary supplements.

By Jennifer Lefton, MS, RD/N, CNSC, FAND
Jennifer Lefton, MS, RD/N-AP, CNSC, FAND is a Registered Dietitian/Nutritionist and writer with over 20 years of experience in clinical nutrition. Her experience ranges from counseling cardiac rehabilitation clients to managing the nutrition needs of complex surgical patients.

Originally written by Cathy Wong