Anticoagulants:
e.g. Warfarin (Coumadin)Devil's claw should not taken with anticoagulant drugs (blood-thinners), such as warfarin (coumadin). Taken together, they may increase the risk of bleeding or cause spontaneous bleeding.
Metformin:
Metformin (Glucophage) is used as a treatment for hyperglycemia in people with type 2 non-insulin dependent diabetes mellitus. Based on one animal study, which found devil's claw extract reduced blood glucose in fasted normal and diabetic animals, metformin should not be combined with devil's claw unless under the supervision of a qualified health practitioner.Insulin or Insulin Analogs:
Insulin and Insulin Analogs (e.g. (Lantus), (NovoLog), (Humalog), (Apidra)) are used for diabetes mellitus, a metabolic disorder in which the pancreas does not make enough insulin. One animal study found devil's claw extract reduced blood glucose in fasted normal and diabetic animals. Based on these preliminary findings, do not take these drugs together with devil's claw.Sulfonylureas:
e.g. Glyburide (Diabeta, Glynase, Micronase), Glipizide (Glucotrol), Glimepiride (Amaryl)Sulfonylureas helps to treat type 2 diabetes mellitus. One drug in this class, called chlorpropamide, is used as a treatment for diabetes insipidus. Based on one animal study, which found devil's claw extract reduced blood glucose in fasted normal and diabetic animals, sulfonylureas should not be combined with devil's claw unless under the supervision of a qualified health practitioner.Sources
Griffith, H. Winter. Complete Guide to Prescription and Nonprescription Drugs 2006 Edition. New York: Perigree, 2005.
Mahomed IM and Ojewole JA. "Analgesic, antiinflammatory and antidiabetic properties of Harpagophytum procumbens DC (Pedaliaceae) secondary root aqueous extract." Phytotherapy Research. 18.12 (2004):982-9.