As many as five percent of Americans suffer from chronic venous insufficiency, a condition closely linked to varicose veins, ankle swelling, pain, itchiness, and nighttime leg cramping. In their efforts to treat this condition, some patients turn to grape seed extract (an antioxidant-rich substance thought to strengthen the blood vessels and stimulate circulation).
While grape seed extract is a fairly popular remedy for chronic venous insufficiency, few studies have tested its effectiveness. For instance, a 2005 research review concluded that there's not yet enough evidence to support the use of grape seed extract in treatment of chronic venous insufficiency.
A condition that occurs when veins fail to efficiently send blood from the legs back to the heart, chronic venous insufficiency may improve with certain lifestyle changes (such as avoiding long periods of sitting or standing). Some patients may also benefit from the use of compression stockings, while others may require surgery. Read the article: Grape Seed Extract for Chronic Venous Insufficiency.