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What You Need to Know About Hesperidin


Updated June 27, 2014

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

Hesperidin is a natural substance found primarily in unripe citrus fruit. Also available in supplement form, hesperidin is classified as a "bioflavonoid" (a type of compound with antioxidant effects).

Uses for Hesperidin

Hesperidin is thought to have beneficial effects on the blood vessels. It's touted as a natural remedy for a number of health problems, including:

Hesperidin is also said to improve circulation, reduce inflammation, and help prevent cancer.

Benefits of Hesperidin

Research on the health effects of hesperidin is fairly limited. However, there's some evidence that hesperidin may offer certain health benefits, although most of the studies are older. Here's a look at some key study findings:

1) Chronic Venous Insufficiency

A condition in which the veins do not efficiently return blood from the legs to the heart, chronic venous insufficiency is linked to problems like varicose veins, ankle swelling, and nighttime leg cramping. Supplements containing a combination of hesperidin, extract of the herb butcher's broom, and ascorbic acid (a form of vitamin C) may help treat chronic venous insufficiency, according to a 2007 study published in International Angiology. (

The study involved 124 people with chronic venous insufficiency. Every day for eight weeks, all study members took two capsules of the hespiridin/butcher's broom/ascorbic acid formula. Starting in the second week of the study, participants showed significant improvements in their symptoms (including pain, cramps, and swelling). The study's authors suggest that the hespiridin/butcher's broom/ascorbic acid may help treat chronic venous insufficiency by producing beneficial effects in patients' blood vessels.

2) Hemorrhoids

In a 1994 study from Angiology, a supplement containing a combination of hespiridin and diosmin (another antioxidant compound available in citrus fruits) was found to aid in the treatment of hemorrhoids. For the study, 100 patients suffering from a hemorrhoid attack were treated with either the hespiridin/diosmin combination or a placebo for seven days. Compared to the placebo group, members of the supplement group showed significantly greater improvement in symptoms.

More recent research on the use of hespiridin in treatment of hemorrhoids is lacking.

3) Osteoporosis

Hesperidin shows promise for the prevention for postmenopausal osteoporosis, a 2003 study from the Journal of Nutrition suggests. In tests on mice, researchers discovered that a hesperidin-rich diet helped inhibit bone loss in animals whose ovaries had been removed.

4) High Cholesterol

Preliminary research indicates that a combination of hesperidin and vitamin E may help keep cholesterol in check. In a 2001 study on rats (published in the International Journal for Vitamin and Nutrition Research), scientists found that supplementing the animals' high-cholesterol diets with hesperidin and vitamin E helped reduce cholesterol levels in their blood.

5) Cancer

Hesperidin may offer anti-cancer benefits, according to a preliminary study published in Phytotherapy Research in 2010. In tests on human breast cancer and prostate cancer cells, the study's authors found that hesperidin inhibited the spread and growth of cancer cells.

Is Hesperidin Safe?

Hesperidin is likely safe when used orally for less than a year. However, it may be unsafe for people taking certain medications (including anticoagulants, blood pressure drugs, and calcium channel blockers). Therefore, it's important to consult your physician if you're considering using hesperidin in combination with other medications.

In addition, hesperidin may be unsafe for people with blood disorders.

Hesperidin Side Effects

Hesperidin may trigger a number of side effects, including abdominal pain, diarrhea, and nausea.

Where to Find Hesperidin

Widely available for purchase online, hesperidin supplements are sold in many natural-food stores and in stores specializing in dietary supplements.


Aguilar Peralta GR, Arévalo Gardoqui J, Llamas Macías FJ, Navarro Ceja VH, Mendoza Cisneros SA, Martínez Macías CG. "Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients." Int Angiol. 2007 Dec;26(4):378-84.

Chiba H, Uehara M, Wu J, Wang X, Masuyama R, Suzuki K, Kanazawa K, Ishimi Y. "Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice." J Nutr. 2003 Jun;133(6):1892-7.

Cospite M. "Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids." Angiology. 1994 Jun;45(6 Pt 2):566-73.

Lee CJ, Wilson L, Jordan MA, Nguyen V, Tang J, Smiyun G. "Hesperidin suppressed proliferations of both human breast cancer and androgen-dependent prostate cancer cells." Phytother Res. 2010 Jan;24 Suppl 1:S15-9.

Park YB, Do KM, Bok SH, Lee MK, Jeong TS, Choi MS. "Interactive effect of hesperidin and vitamin E supplements on cholesterol metabolism in high cholesterol-fed rats." Int J Vitam Nutr Res. 2001 Jan;71(1):36-44.

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