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What You Need to Know About Beta-Glucan


Updated July 16, 2013

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

Beta-glucan is a substance found naturally in several foods, including oats, barley, and certain mushrooms. Also found in yeasts, beta-glucan is classified as a polysaccharide (a large molecule made up of multiple sugar molecules). There's some evidence that beta-glucan may offer a number of health benefits, such as stimulation of the immune system.

Benefits of Beta-Glucan

Here's a look at some key study findings on the possible health benefits of beta-glucan:

1) Cholesterol

The beta-glucan found in oats may help keep cholesterol in check, according to a 2011 report from Nutrition Reviews. Looking at studies conducted over the previous 13 years, the report's authors determined that oat-derived beta-glucan may significantly reduce levels of total and LDL ("bad") cholesterol. On average, the authors note, daily oat consumption is associated with 5 percent and 7 percent reductions in total and LDL cholesterol levels, respectively.

2) Diabetes

Beta-glucan may help manage diabetes, a 2008 research review from Vascular Health and Risk Management suggests. Analyzing previous research on beta-glucan and diabetes, the review's authors found that dietary intake of beta-glucan may help protect against diabetes-related complications by controlling blood sugar levels, lowering cholesterol, and keeping blood pressure in check.

3) Cancer

Preliminary research indicates that beta-glucan may activate a number of cells and proteins that fight cancer (such as T-cells and natural killer cells). What's more, tests on animals have shown that beta-glucan may inhibit the spread of cancer cells. However, a 2009 report in the Journal of Hematology and Oncology cautions that there are "no good quality clinical trial data" for the effectiveness of beta-glucan in treating cancer.

4) Immunity

Currently, there is a lack of clinical trials supporting the claim that beta-glucan can rev up the immune system and stave off colds, flu, and other types of infection. However, some preliminary research suggests that beta-glucan may strengthen the immune system and knock out viruses.

In a 2004 study from Medicine and Science in Sports and Exercise, for instance, tests on mice revealed that beta-glucan may offset the negative effects of exercise-induced stress and increase the immune system's defense against upper respiratory tract infections.

Uses for Beta-Glucan

In addition to being available in foods, beta-glucan is sold in supplement form. Proponents claim that beta-glucan supplements can help with the following health problems:

  • allergies
  • asthma
  • Crohn's disease
  • chronic fatigue syndrome
  • diabetes
  • fibromyalgia
  • high cholesterol
  • rheumatoid arthritis
  • ulcerative colitis

Beta-glucan is also purported to strengthen the immune system and, in turn, fend off colds, flu, and even cancer. Additionally, beta-glucan is said to increase the body's defense against the harmful effects of stress.

Where to Find Beta-Glucan Supplements

Beta-glucan supplements are widely available for purchase online, and are also sold in many natural-food stores and in stores specializing in dietary supplements.

Many beta-glucan supplements source their beta-glucan from substances like baker's yeast. Others contain medicinal mushrooms like shiitake and maitake (both found to be rich in beta-glucan). While research on the health effects of medicinal mushroom supplements is somewhat limited, a number of studies suggest that they can help boost immunity.


Although beta-glucan is generally considered safe, there's some concern that it may lower blood sugar. Therefore, people with hypoglycemia (or anyone taking medications to reduce blood sugar) should consult a physician before using beta-glucan.

Using Beta-Glucan Supplements for Health

Although it's too soon to recommend beta-glucan supplements for health purposes, increasing your beta-glucan intake (by including oats, barley, and medicinal mushrooms in your diet) may help enhance your overall health.

If you're considering the use of beta-glucan supplements in treatment of a chronic condition, make sure to talk to your doctor before starting your supplement regimen.


American Cancer Society. "Maitake Mushrooms." November 2008.

Chan GC, Chan WK, Sze DM. "The effects of beta-glucan on human immune and cancer cells." J Hematol Oncol. 2009 Jun 10;2:25.

Chen J, Raymond K. "Beta-glucans in the treatment of diabetes and associated cardiovascular risks." Vasc Health Risk Manag. 2008;4(6):1265-72.

Davis JM, Murphy EA, Brown AS, Carmichael MD, Ghaffar A, Mayer EP. "Effects of oat beta-glucan on innate immunity and infection after exercise stress." Med Sci Sports Exerc. 2004 Aug;36(8):1321-7.

Othman RA, Moghadasian MH, Jones PJ. "Cholesterol-lowering effects of oat β-glucan." Nutr Rev. 2011 Jun;69(6):299-309. doi: 10.1111/j.1753-4887.2011.00401.x.

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