Carbonic Anhydrase Inhibitors:
Carbonic anhydrase inhibitors are used to treat glaucoma, epileptic seizures, fluid retention, and altitude sickness. These drugs should not be used with white willow, which contains salicylates, due to an increased risk of salicylate toxicity.
Cox-2 Selective Nonsteroidal Anti-Inflammatory Drugs (NSAIDS):
Cox-2 Inhibitors are used to treat rheumatoid arthritis symptoms, pain, fever, and inflammation, dysmenorrhea, and colorectal polyps. No interactions with white willow bark have been reported at the time of writing. However, until we have further research on the safety of white willow bark, they should not be combined because Cox-2 inhibitors are not recommended with aspirin due to an increased risk of stomach ulcers.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDS):
Nonsteroidal anti-inflammatory drugs combined with white willow bark may increase the risk of stomach ulcers.
Platelet inhibitors are used to reduce the risk of heart attack or stroke and for patients who have had a coronary stent implant. Like aspirin, white willow contains salicylates which may thin blood, so it can increase the risk of bleeding.
White willow bark contains salicylates and should not be combined with anticoagulants. They may increase the risk of bleeding or cause spontaneous bleeding.