1. Health
You can opt-out at any time. Please refer to our privacy policy for contact information.

Health Benefits of Shiitake Mushrooms

What Should I Know About It?


Updated June 11, 2014

Written or reviewed by a board-certified physician. See About.com's Medical Review Board.

Shiitake is a medicinal mushroom used as a natural remedy for a host of health conditions.

Health Benefits of Shiitake Mushrooms:

To date, there is limited scientific support for claims of shiitake's health effects. While findings from animal studies and test-tube research suggest that shiitake may offer certain health benefits, few clinical trials have tested shiitake's effectiveness in treating or preventing any condition. Here's a look at some key study findings:

1)Colon Cancer

Shiitake contains lentinan, a type of beta glucan (an immune-enhancing substance found in other medicinal mushrooms, including maitake). Laboratory research indicates that lentinan may help stimulate the immune system by triggering activity in immune cells (such as natural killer cells and T-cells). In a 2002 study on mice, researchers found that shiitake-extracted lentinan helped hinder the animals' development of colon cancer.

2) Prostate Cancer

For a study published in 2002, 62 men with prostate cancer took shiitake-containing capsules three times daily for six months. Study results showed that the disease stabilized in only four patients during the treatment period, while 23 patients experienced a progression in their prostate cancer. Given these findings, the study's authors concluded that shiitake extract alone is ineffective as a prostate cancer treatment.

3) Cavities

Preliminary research suggests that shiitake may help stop tooth decay. In a 2000 study on rats, scientists discovered that shiitake-fed animals were less likely to develop cavities (compared to rats that weren't fed shiitake).

Common Uses for Shiitake Mushrooms:

Long used in traditional Chinese medicine, shiitake is said to boost the immune system and protect against problems ranging from the common cold to cancer. Proponents claim that shiitake can also help treat infections (such as a hepatitis), lower cholesterol levels, and aid in the prevention of heart disease.

Is Shiitake Safe?

Although shiitake is generally considered safe when taken in supplement form, there's some evidence that long-term use of shiitake may lead to dermatitis.

Sold fresh or dried in most grocery stores, whole shiitake mushrooms can safely be used in cooking. However, little is known about the health benefits of consuming shiitake as a whole food.

Using Shiitake for Health:

If you're considering the use of a shiitake supplement in treatment of prevention of a specific health problem, consult your doctor before beginning your supplement regimen.


American Cancer Society. "Shiitake Mushroom".

deVere White RW, Hackman RM, Soares SE, Beckett LA, Sun B. "Effects of a mushroom mycelium extract on the treatment of prostate cancer." Urology. 2002 Oct;60(4):640-4.

Ng ML, Yap AT. "Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes)." J Altern Complement Med. 2002 Oct;8(5):581-9.

Shouji N, Takada K, Fukushima K, Hirasawa M. "Anticaries effect of a component from shiitake (an edible mushroom)." Caries Res. 2000 Jan-Feb;34(1):94-8.

  1. About.com
  2. Health
  3. Alternative Medicine
  4. Supplements
  5. A - Z Supplement Index
  6. Three Health Benefits of Shiitake Mushrooms

©2014 About.com. All rights reserved.

We comply with the HONcode standard
for trustworthy health
information: verify here.