Supplements Herbal Supplements Jiaogulan: Uses, Side Effects, & More Jiaogulan (Gynostemma pentaphyllum), a traditional Chinese herb, shows potential for managing diabetes, body composition, and reducing stress. By Megan Nunn, PharmD Updated on May 19, 2023 Medically reviewed by Suzanne Fisher, RD Print Verywell / Anastasia Tretiak Table of Contents View All Table of Contents Uses Side Effects Precautions Dosage Toxicity Interactions Storage Similar Supplements FAQ Jiaogulan (Gynostemma pentaphyllum) is a climbing vine found in China and other parts of Asia. The plant is used in traditional Chinese medicine (TCM). Jiaogulan, also known as fairy herb and southern ginseng, is sold as a supplement that’s claimed to have benefits for diabetes, high cholesterol, and anxiety. The plant’s saponins (organic chemicals) are thought to be responsible for some of its effects. This article looks at some of Jiaogulan’s possible health benefits and side effects. It also goes over where to buy the supplement and how to take it. Unlike drugs, dietary supplements are not regulated in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Choose a supplement tested by a trusted third party, such as USP, ConsumerLab, or NSF, when possible.However, even if supplements are third-party tested, it doesn't mean they are necessarily safe for all or effective in general. Therefore, talking to your healthcare provider about any supplements you plan to take and checking in about potential interactions with other supplements or medications is important. Supplement Facts Active ingredients: Gypenoside saponins, polysaccharides, flavonoids, amino acids, and phytosterols Alternate names: Gynostemma pentaphyllum, bellflower, fairy herb, gospel herb, miracle grass, sweet tea vine, poor man's ginseng, southern ginseng Legal status: Over-the-counter (OTC) supplement in the United States Suggested dose: 225 milligrams twice a day Safety considerations: Not recommended during pregnancy or breastfeeding Uses of Jiaogulan Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. No supplement is intended to treat, cure, or prevent disease. Much of the research evidence supporting jiaogulan is limited to lab studies in mice and other animals. Small clinical trials and most human research on using jiaogulan has been on diabetes, obesity, and stress. While jiaogulan has shown potential for helping with some health conditions, more human research and more extensive trials are needed before it can be recommended for these uses. Stress: Jiaogulan is one of many medicinal herbs thought to relieve stress. A study in South Korea looked at 72 people with a history of chronic stress and anxiety. Half were given an extract from jiaogulan leaves and the other half got a placebo. The participants continued taking the supplement for eight weeks and were assessed for stress. The researchers found lower self-reported stress levels in the jiaogulan group but no differences in the levels of stress hormones like norepinephrine and cortisol between people taking jiaogulan and those taking a placebo. Diabetes: In one small study, 16 people newly diagnosed with type 2 diabetes were given either 6 grams per day of jiaogulan tea or green tea for four weeks. The jiaogulan was found to improve the body's response to insulin. In another small study, 25 people with type 2 diabetes were given a blood sugar–lowering medicine for four weeks and then randomly assigned to take either 6 grams (g) a day of jiaogulan tea or a green tea placebo for eight additional weeks. The group that used the jiaogulan tea in addition to the standard diabetes medication achieved better blood sugar control, demonstrated by decreased hemoglobin A1C and fasting plasma glucose levels. Obesity: Jiaogulan may affect body composition. In one study, researchers gave either 450 milligrams (mg) of a commercial jiaogulan extract called ActivAMP or a placebo treatment daily to 117 people assigned male or female at birth who were overweight. At the end of 16 weeks, the jiaogulan group showed a significant reduction in the oft-controversial body mass index (BMI), and total fat mass and total body weight, compared to the placebo group. With obesity, the research suggests some differences between people assigned male or female at birth. People assigned male at birth who took jiaogulan had significant decreases in visceral fat (around internal organs) while people assigned female at birth had reductions in gynoid fat (around the hips, thighs, and breasts). The researchers said that the study supported earlier research that had similar findings. BMI is a dated, flawed measure. It does not take into account factors such as body composition, ethnicity, sex, race, and age. Even though it is a biased measure, BMI is still widely used in the medical community because it’s an inexpensive and quick way to analyze a person’s potential health status and outcomes. Additional Uses In addition to the potential health benefits listed above, preliminary studies in a test tube or animal models have looked at jiaogulan for the following conditions: Cancer High cholesterol Alzheimer's disease Vascular dementia Parkinson's disease Liver injury Aging Exercise endurance However, Jiaogulan is not recommended for these purposes because there is not enough research in humans to show that it’s safe or effective for these conditions. What Are the Side Effects of Jiaogulan? Your healthcare provider may recommend trying jiaogulan if you have diabetes, anxiety, or another condition. However, consuming an herb like jiaogulan may have side effects that can be mild or severe. Common Side Effects Jiaogulan is generally thought of as safe, but it can cause the following side effects: Vomiting Diarrhea Constipation Dizziness Blurred vision Tinnitus (a ringing or other sounds in the ear) Severe Side Effects While there are no reports of severe side effects from jiaogulan, it’s not known if they are possible because there has not been enough research in humans. Precautions Keep these precautions in mind if you plan to try taking jiaogulan: Severe allergic reaction: Do not use jiaogulan if you have a known allergy to it or its ingredients. Ask your pharmacist or healthcare provider for a complete list of the ingredients if you're unsure.Chronic medical conditions: You should always ask your provider before taking a supplement like jiaogulan if you have a chronic health condition—for example, an autoimmune disease like lupus or rheumatoid arthritis. Herbs and supplements may affect your disease (e.g., could trigger a flare-up of symptoms) or the medications or other treatments you use to manage it. Blood clotting problems: Ask your provider about using jiaogulan if you have any problems with blood clotting or bleeding.Diabetes: If you are taking insulin or other drugs to regulate your blood sugar, you need to be careful about jiaogulan because it can lead to low blood sugar levels.Surgery: You may need to avoid taking certain supplements, OTC, and prescription medications before you have surgery. Ask your provider if you are not sure what you can continue to take leading up to your surgery.Pregnancy and breastfeeding: There is no evidence of the safety of using jiaogulan during pregnancy or when breastfeeding. It should not be used by people planning to become pregnant as one of its components, ginsenoside, has been found to cause fetal abnormalities in rats. Dosage: How Much Jiaogulan Should I Take? Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs and that it will not interact with other medications you take. Jiaogulan has been studied at doses of 450 mg daily for up to 16 weeks for obesity. Studies on jiaogulan for chronic stress used 400 mg daily for eight weeks. In clinical trials, the daily dose was typically divided into morning and evening doses. What Happens if I Take Too Much Jiaogulan? Toxicity from jiaogulan has not been reported in clinical trials. In one human study, doses of up to 800 mg a day for two months appeared to be safe. However, since there is not enough research on humans to know for sure how much is too much to take, you should watch yourself for side effects and follow the directions your provider has given you. Interactions Components in jiaogulan called gypenosides have been shown to inhibit an enzyme in the liver known as cytochrome P450 2D6 (CYP2D6). CYP2D6 is responsible for breaking down (metabolizing) some medications. Taking jiaogulan may cause medicines broken down by CYP2D6 enzymes to build up in the body. If they build up too much, it can lead to toxicity. Examples of these medications include: Blood clotting medications (e.g., warfarin)Medications that suppress the immune system (e.g., steroids)Pamelor (nortriptyline)Paxil (paroxetine)Prozac (fluoxetine)Haldol (haloperidol)Risperdal (risperidone)Tambocor (flecainide)Rythmol (propafenone)Opioids If you take any of these prescription medications, ask your healthcare provider before you start using jiaogulan. Diabetes Treatment Jiaogulan may lower blood sugar. If you use insulin and other diabetes medicines to control your blood sugar, you need to be very careful about using the herb. If you take it with your diabetes medications, it could make your blood sugar go too low (hypoglycemia). Medications commonly used to control blood sugar if you have diabetes include: Glucophage (metformin)Actos (pioglitazone)Glucotrol (glipizide)Januvia (sitagliptin) It is essential to carefully read a supplement's ingredients list and nutrition facts panel to learn which ingredients are in the product and how much of each ingredient is included. Please review this supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications. How to Store Jiaogulan Store jiaogulan in a cool, dark, and dry place in your home. Keep away from children and animals. Discard after one year or as directed by the manufacturer. Similar Supplements Other herbal products sometimes used for diabetes or its complications include: Panax ginsengAstragalus membranaceusMomordica charantia (bitter melon)Ganoderma lucidum Some other supplements that could play a role in lowering the body's stress response include: AshwagandhaSaint-John's-wortCannabidiol (CBD)CurcuminBlack cohoshGreen teaAmerican ginsengGinkgo bilobaHoly basil Other herbal supplements traditionally used for their anti-aging effects include: GinsengRadix AstragaliGanoderma lucidumGinkgo biloba Summary Jiaogulan has historically been used medicinally for a range of health conditions. While some human research has looked at using the herb for diabetes, obesity, and stress, the studies have been limited. The herb is considered generally safe to use, but some people may need to be careful taking it or not take it at all. Always ask your provider before starting any supplement, especially if you have a chronic health condition or are taking other medications or OTC products. Frequently Asked Questions What sort of changes in body composition can I expect with jiaogulan? Research has shown that body composition changes with jiaogulan are modest. In a 16-week trial, people taking jiaogulan lost less than 2 pounds (1 kilogram). Is jiaogulan safe to take long-term? It’s not known if jiaogulan is safe for long-term use. Clinical trials have studied the effects of the herbal extract for up to four months. More research is needed to determine long-term safety. Is jiaogulan a true ginseng? Ginseng is a generic name for plant species in the genus Panax. Some forms of ginseng that have been used medicinally include Panax quinquefolius (American ginseng), Panax ginseng (Chinese/Korean ginseng), and Panax japonicus (Japanese ginseng). Jiaogulan is not a true ginseng because it is not in the Panax genus but contains many of the same active components, called saponins, found in ginseng. 20 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: A double-blind, randomised, placebo-controlled study. J Hum Nutr Diet. 2022;35(3):583-589. doi:10.1111/jhn.12936 Su C, Li N, Ren R, et al. Progress in the Medicinal Value, Bioactive Compounds, and Pharmacological Activities of Gynostemma pentaphyllum. Molecules. 2021;26(20):6249. Published 2021 Oct 15. doi:10.3390/molecules26206249 National Center for Biotechnology Information. PubChem Substance Record for SID 472389889, CODONOPSIS PILOSULA WHOLE, Source: FDA Global Substance Registration System (GSRS). https://pubchem.ncbi.nlm.nih.gov/substance/472389889. Choi E-K, Won YH, Kim S-Y, et al. Supplementation with extract of Gynostemma pentaphyllum leaves reduces anxiety in healthy subjects with chronic psychological stress: A randomized, double-blind, placebo-controlled clinical trial. Phytomedicine. 2019;52:198-205. doi: 10.1016/j.phymed.2018.05.002 Huyen VTT, Phan DV, Thang P, et al. Gynostemma pentaphyllum tea improves insulin sensitivity in type 2 diabetic patients. Journal of Nutrition and Metabolism. 2013;2013:e765383. doi: 10.1155%2F2013%2F765383 Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients. Evid Based Complement Alternat Med. 2012;2012:452313. doi:10.1155/2012/452313 Park SH, Huh TL, Kim SY, et al. Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo-controlled trial [published correction appears in Obesity (Silver Spring). 2015 Dec;23(12):2520] [published correction appears in Obesity (Silver Spring). 2020 Sep;28(9):1770-1773]. Obesity (Silver Spring). 2014;22(1):63-71. doi:10.1002/oby.20539 Jeenduang N, Sangkaew B, Chantaracha P, et al. APOE and CETP TaqIB polymorphisms influence metabolic responses to Hibiscus sabdariffa L. and Gynostemma pentaphyllum Makino tea consumption in hypercholesterolemic subjects. Asia Pac J Clin Nutr. 2017;26(2):368-378. doi:10.6133/apjcn.122015.04 Phu HT, Thuan DTB, Nguyen THD, Posadino AM, Eid AH, Pintus G. Herbal Medicine for Slowing Aging and Aging-associated Conditions: Efficacy, Mechanisms and Safety. Curr Vasc Pharmacol. 2020;18(4):369-393. doi:10.2174/1570161117666190715121939 Ji X, Shen Y, Guo X. Isolation, Structures, and Bioactivities of the Polysaccharides from Gynostemma pentaphyllum (Thunb.) Makino: A Review. Biomed Res Int. 2018;2018:6285134. Published 2018 Oct 16. doi:10.1155/2018/6285134 Shaito A, Thuan DTB, Phu HT, et al. Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety. Front Pharmacol. 2020;11:422. Published 2020 Apr 7. doi:10.3389/fphar.2020.00422 Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum].1993;13(5):278-261. Wang L, Gao S, Jiang W, et al. Antioxidative dietary compounds modulate gene expression associated with apoptosis, DNA repair, inhibition of cell proliferation and migration. Int J Mol Sci. 2014;15(9):16226-16245. Published 2014 Sep 15. doi:10.3390/ijms150916226 Chan LY. An in-vitro study of ginsenoside Rb1-induced teratogenicity using a whole rat embryo culture model. Human Reproduction. 2003;18(10):2166-2168. doi:https://doi.org/10.1093/humrep/deg401 He M, Jiang J, Qiu F, et al. Inhibitory effects of gypenosides on seven human cytochrome P450 enzymes in vitro. Food Chem Toxicol. 2013;57:262-265. doi:10.1016/j.fct.2013.03.041 Bertilsson L, Dahl ML, Dalén P, Al-Shurbaji A. Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs. Br J Clin Pharmacol. 2002;53(2):111-122. doi:10.1046/j.0306-5251.2001.01548.x Hamid K, Alqahtani A, Kim MS, et al. Tetracyclic triterpenoids in herbal medicines and their activities in diabetes and its complications. Curr Top Med Chem. 2015;15(23):2406-2430. doi:10.2174/1568026615666150619141940 Lopresti AL, Smith SJ, Drummond PD. Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials. Nutr Neurosci. 2022;25(8):1704-1730. doi:10.1080/1028415X.2021.1892253 Palisin TE, Stacy JJ. Ginseng: is it in the root?. Curr Sports Med Rep. 2006;5(4):210-214. doi:10.1097/01.csmr.0000306509.57644.71 Nguyen NH, Ha TKQ, Yang JL, Pham HTT, Oh WK. Triterpenoids from the genus Gynostemma: Chemistry and pharmacological activities. J Ethnopharmacol. 2021;268:113574. doi:10.1016/j.jep.2020.113574 Additional Reading Choi HS, Zhao TT, Shin KS, et al. Anxiolytic effects of herbal ethanol extract from Gynostemma pentaphyllum in mice after exposure to chronic stress. Molecules. 2013;18(4):4342-56. doi: 10.3390/molecules18044342 Park SH, Huh TL, Kim SY, et al. Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): A randomized, double-blind, placebo-controlled trial. Obesity (Silver Spring). 2013. doi: 10.1002/oby.20539. Tan Y, Kamal MA, Wang ZZ, Xiao W, Seale JP, Qu X. Chinese herbal extracts (SK0506) as a potential candidate for the therapy of the metabolic syndrome. Clin Sci (Lond). 2011;120(7):297-305. doi: 10.1042/CS20100441. By Megan Nunn, PharmD Nunn is a community pharmacist in Tennessee with 12 years of experience in medication counseling and immunization. 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