Health Benefits of 12 Ayurvedic Herbs

Gotu kola capsules, Triphala capsules, Guggul capsules, Boswellia softgels

Verywell / Anastasia Tretiak

Ayurvedic herbs are used in the practice of Ayurveda, an ancient Indian healing system that focuses on balancing the mind, body, and environment.

Ayurvedic medicine aims to prevent illness—rather than respond to disease—by maintaining this balance.

Ayurvedic herbs have been studied in clinical trials for conditions like the following:

This article discusses some potential benefits of 12 Ayurvedic herbs. It also looks at drug interactions, side effects, and other things you should consider when taking these herbs.

Remember that this information summarizes recent scientific evidence about these products and is not exhaustive.

Warning

Ayurvedic herbs, particularly those used for rasa shastra or "detoxification," often include high levels of toxic heavy metals.

Studies have found that 20%-65% of Ayurvedic herbs online contain more than the acceptable daily amounts of the following toxic heavy metals:

Taking these contaminated supplements can increase your risk of heavy metal toxicity (e.g., lead or mercury poisoning).

If given to children, contaminated supplements can contribute to irreparable harm, including the following:

  • Intellectual disability
  • Neurocognitive disorders (brain and nerve disorders that lead to issues with how one thinks)
  • Behavioral disorders
  • Respiratory conditions
  • Cancer
  • Cardiovascular disease

To help ensure quality and safety, consider these steps:

  • Select carefully: Buy your Ayurvedic herbs from a reputable manufacturer with an established market presence.
  • Verify health claims: Don't be swayed by the assertion that "natural" treatments are inherently better or any health claims that may or may not be accurate.
  • Talk to your healthcare provider: Use your best judgment and always keep your healthcare provider in the loop about any integrative therapies or supplements you take. While herbs may have some benefits, self-treating a medical condition or avoiding or delaying standard medical care can have serious consequences.

Amla (Indian Gooseberry)

Amla is a fruit with antioxidant properties high in ascorbic acid (vitamin C) and polyphenols.

It may decrease the following major lipids:

Additionally, amla can lower what's known as the atherogenic index of plasma, a ratio of triglycerides to high-density lipoprotein cholesterol (HDL, or "good" cholesterol). Decreasing this ratio is associated with a lower risk of heart disease.

Amla may reduce blood glucose and C-reactive protein (CRP) levels, a marker of inflammation.

And it's been shown to decrease the symptoms and severity of gastroesophageal reflux disease (GERD) by almost 50% compared to placebo.

Ashwagandha (Withania somnifera)

Ashwagandha, also known as Indian ginseng or winter cherry, has been studied for many conditions.

Research suggests it can improve brain functions like attention and reaction time.

Ashwagandha has also been shown to reduce anxiety and levels of the stress hormone cortisol. It is believed to act as an adaptogen, a substance that helps protect the body from stress.

And because ashwagandha may boost testosterone levels in males by 15% or more, it is also touted to improve male sexual health.

Brahmi (Bacopa monnieri)

Brahmi is a purple flowering herb commonly used to improve memory and cognition (thinking).

Some studies have found that participants who took brahmi saw an improved ability to pay attention and collect, store, and recall information.

One small study showed that people with Alzheimer's disease benefited from taking 600 milligrams of brahmi daily, but it wasn't compared to a placebo or another treatment.

Cardamom (Elettaria cardamomum)

Cardamom is a herb in the ginger family that contains antioxidants and anti-inflammatory compounds.

It can be used during pregnancy to alleviate nausea and vomiting.

It's also been studied for possible metabolic benefits, but the results were inconclusive. One review determined that taking cardamom for up to three months may help with glucose metabolism but had no effect on body mass index (BMI), weight, or waist circumference.

Cardamom may also help lower blood pressure in people with metabolic syndrome, though more robust trials are needed to confirm this.

Guggul (Commiphora mukul)

Guggul is a gum resin made from drying the sap of Commiphora or Boswellia shrubs. It has traditionally been used for arthritis, diabetes, and inflammatory bowel disease (IBD).

In studies, guggul decreased total cholesterol levels by over 6% and LDL cholesterol by 10%. Research shows that lowering cholesterol by 10% translates to a 38% lower risk of heart events at age 50.

Guggul has also been shown to increase HDL ("good") cholesterol levels, which can protect the heart.

Garlic (Allium sativum)

A common culinary spice, garlic is an Ayurvedic herb that has been shown to lower total and LDL cholesterol levels by around 5-6% in people with high cholesterol.

It may also help decrease blood pressure and fasting blood sugar, and protect against cancer.

Guduchi (Tinospora cordifolia)

Guduchi, also called giloy, is used in Indian folk medicine to treat diabetes, stomachache, jaundice, urinary problems, and dysentery.

Guduchi has been studied as an add-on therapy to aid recovery from COVID-19, for diabetes management, and to alleviate the effects of alcohol use disorder.

However, more research is needed to confirm its effects on these conditions.

Neem (Azadirachta indica)

Also known as "nature's drug store," neem has potent antioxidant effects.

It may help prevent or treat cancer, although more information is needed to verify its effects.

It has shown benefits for skin conditions, including psoriasis.

It may also act as a contraceptive at different points in the reproductive process to prevent pregnancy, but more research is needed.

Some weak studies suggest that neem is about as effective as chlorhexidine mouthwash in reducing dental plaque in people with gingivitis.

Shatavari (Asparagus racemosus)

In Ayurveda, shatavari is a Rasāyana herb used to maintain homeostasis (balance in the body) and slow aging.

Translated as "able to have one hundred husbands," shatavari has traditionally been used to promote lactation and increase fertility.

It may help with infertility, hormonal imbalances, and polycystic ovary syndrome (PCOS), but more clinical evidence is needed.

Shatavari has also been studied for its effect against Alzheimer's Disease and viruses like COVID-19. However, more study is needed.

Turmeric (Curcuma longa)

Turmeric is a plant in the ginger family used to make curry powder.

Some research says turmeric may provide therapeutic benefits for skin health as an oral supplement or topical (on the skin) application.

Turmeric and its active ingredient, curcumin, may be as effective as non-steroidal anti-inflammatory medicines (NSAIDs) for joint pain, function, and stiffness in people with osteoarthritis (OA). Research suggests it should be used for at least 12 weeks for this indication.

Another review found that turmeric may decrease inflammation due to OA and other types of arthritis, such as ankylosing spondylitis (AS), rheumatoid arthritis (RA), and gout. More robust clinical trials are needed to confirm this effect of turmeric.

Some research also suggests that adding curcumin to standard treatments for depression can reduce symptoms.

Triphala

Triphala is not one Ayurvedic herb but a botanical formula that contains three different ones:

  • Terminalia bellirica
  • Terminalia chebula
  • Emblica officinalis (Amla)

Triphala is primarily used in Ayurveda for disorders of the gastrointestinal tract, but most of the data supporting this use comes from animal studies.

Limited research suggests that triphala may decrease some people's cholesterol, triglycerides, blood sugar, weight, and BMI. However, more large clinical trials are needed to confirm this.

Triphala may also be used for dental conditions like cavities, gingivitis, and thrush.

Tulsi (Holy Basil)

Tulsi has been studied in small clinical trials for its effects on cognitive function.

In one, it was shown to improve symptoms of stress by 39% versus placebo (a sugar pill with no medicine). In another, it decreased reaction time and rate of error when given to healthy male volunteers.

According to limited clinical trials, it may also boost the immune system's response to infections, decrease asthma symptoms, and lower blood sugar levels. More data is needed to confirm these effects.

Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian nutritionist (RD or RDN), pharmacist, or healthcare provider. No supplement is intended to treat, cure, or prevent disease.

Dosage

Dosage varies depending on the herb used and the condition it's being used for. Ayurvedic herbs have been studied in clinical trials at the following doses:

  • Amla: 500 milligrams (mg) twice a day for cholesterol; 1000 milligrams twice a day for GERD
  • Ashwagandha: 300 milligrams twice a day for brain function or anxiety
  • Brahmi: 250 to 600 milligrams a day for memory
  • Cardamom: 3 grams (g) a day for metabolism
  • Guggul: 200 milligrams, in combination with other herbal supplements, three times a day for blood sugar and cholesterol
  • Garlic: 800 milligrams a day for cholesterol
  • Guduchi: 100 milliliters (mL) extract once daily for alcohol use disorder
  • Neem: 1 to 5 milliliters oil inserted into the vagina to prevent pregnancy or for vaginal infections
  • Shatavari: 1 gram a day for handgrip strength
  • Turmeric: 100 milligrams a day for joint pain
  • Triphala: 5 grams twice a day for blood sugar
  • Tulsi: 300 milligrams a day for brain function

Your healthcare provider, a pharmacist, or a registered dietitian can work with you to determine an appropriate dose if you try one of these herbs.

Safety

Avoid Ayurvedic herbs if you're allergic to them or their components (parts).

Seek immediate medical attention if you have a severe allergic reaction (itching, hives, shortness of breath).

Side Effects

Any herb can cause unwanted side effects. Some side effects of some of the herbs listed include:

  • Amla: Constipation
  • Ashwagandha: Sleepiness, stomach pain, diarrhea, and rarely, liver damage
  • Brahmi: Diarrhea, nausea, stomach cramps
  • Cardamom: Diarrhea, skin inflammation, glossitis (inflamed tongue)
  • Guggul: Headache, skin rash, diarrhea
  • Garlic: Bad breath, body odor, allergic reactions, increased risk of bleeding
  • Guduchi: Liver injury
  • Neem: Liver toxicity, metabolic acidosis, and encephalopathy at high doses (in children); may cause infertility
  • Shatavari: Pink eye, skin reaction, cough
  • Turmeric: Upset stomach
  • Tulsi: Nausea

Avoid long-term use of Ayurvedic herbs unless under the guidance of a qualified healthcare provider. Ideally, your provider will perform specific blood tests to check how your body responds to the herb(s), including:

Stop treatment and call your healthcare provider if you experience any side effects after taking an Ayurvedic herb.

Bring your herbs and supplements to your healthcare provider or the emergency room, so they can review what you take. This will help your healthcare provider determine your best course of treatment.

Interactions

A complete list of possible drug interactions is not possible, but here are a few drugs known to interact with some of these herbs:

To avoid these risks, inform your healthcare provider and pharmacist if you are using or intend to use an Ayurvedic remedy.

Even still, remember that there is still much that is not known about herbal remedies.

Precautions

Due to the lack of quality research, some people should avoid these options.

For the most part, Ayurvedic herbs have not been proven safe for the following groups:

  • Children
  • Pregnant or breastfeeding people

It is not known how Ayurvedic herbs may impact a chronic medical condition.

Guggul capsules

Verywell / Anastasia Tretiak

Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. When possible, choose a supplement tested by a trusted third party, such as the Unites States Pharmacopeia (USP), ConsumerLab, or NSF.org. However, even if supplements are third-party tested, that doesn't mean they are necessarily safe for all or effective in general. Therefore, talking to your healthcare provider about any supplements you plan to take and checking in about potential interactions with other supplements or medications is essential.

Summary

Ayurvedic herbs are used as part of a traditional Indian healing system.

Some studies have found that certain herbs may benefit people with inflammation, high cholesterol, and skin disorders.

However, the evidence is conflicting and limited, so more research is needed.

Side effects of Ayurvedic herbs may include gastrointestinal problems and allergic rash when applied to the skin.

The following groups should avoid Ayurvedic herbs:

  • Children
  • Pregnant or breastfeeding people

Always consult your healthcare provider before taking any kind of supplement.

Frequently Asked Questions

  • What are the signs of heavy metal poisoning?

    Toxicity from heavy metals such as mercury and lead is a risk associated with Ayurvedic herbs.

    Regular exposure to even low doses of heavy metals may cause non-specific signs like fatigue and anxiety.

    Taking high doses of herbs that contain heavy metals, whether intentionally or through contamination, may cause stomach pain, bloody diarrhea, kidney failure, or birth defects.

  • Is Ayurvedic medicine banned in the United States?

    No. According to the National Center for Complementary and Integrative Health (NCCIH), part of the National Institutes of Health, around 240,000 people in the U.S. use Ayurvedic medicine.

    Do keep in mind, though, that Ayurveda is not regulated in the U.S. and that Ayurvedic practitioners are not required to be licensed.

  • Where can I buy Ayurvedic herbs?

    Ayurvedic products are widely available from Ayurvedic practitioners, acupuncturists, stores that sell Indian food, and websites.

69 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Sharma H. Ayurveda: science of life, genetics, and epigenetics. Ayu. 2016;37(2):87-91. doi:10.4103/ayu.AYU_220_16

  2. Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trialJ Evid Based Complementary Altern Med. 2017;22(1):96-106. doi:10.1177/2156587216641830

  3. Kessler CS, Dhiman KS, Kumar A, et al. Effectiveness of an Ayurveda treatment approach in knee osteoarthritis - a randomized controlled trial. Osteoarthritis Cartilage. 2018;26(5):620-630. doi:10.1016/j.joca.2018.01.022

  4. Pandit S, Biswas S, Jana U, De RK, Mukhopadhyay SC, Biswas TK. Clinical evaluation of purified Shilajit on testosterone levels in healthy volunteers. Andrologia. 2016;48(5):570-575. doi:10.1111/and.12482

  5. Gyawali D, Vohra R, Orme-Johnson D, et al. A systematic review and meta-analysis of Ayurvedic herbal preparations for hypercholesterolemia. Medicina (Kaunas). 2021;57(6):546. doi:10.3390/medicina57060546

  6. Hardin J, Seltzer J, Suhandynata R, et al. Severe arsenic poisoning due to Ayurvedic supplements. Clin Case Rep. 2023;11(7):e7733. doi:10.1002/ccr3.7733

  7. Capitão C, Martins R, Santos O, et al. Exposure to heavy metals and red blood cell parameters in children: a systematic review of observational studiesFront Pediatr. 2022;10:921239. doi:10.3389/fped.2022.921239

  8. Gul M, Liu ZW, Iahtisham-Ul-Haq, et al. Functional and nutraceutical significance of amla (Phyllanthus emblica L.): a review. Antioxidants (Basel). 2022;11(5):816. doi:10.3390/antiox11050816

  9. Upadya H, Prabhu S, Prasad A, et al. A randomized, double blind, placebo controlled, multicenter clinical trial to assess the efficacy and safety of Emblica officinalis extract in patients with dyslipidemia. BMC Complement Altern Med. 2019;19(1):27. doi:10.1186/s12906-019-2430-y

  10. Setayesh L, Haghighat N, Rasaei N, et al. The impact of Emblica Officinalis (Amla) on lipid profile, glucose, and C-reactive protein: a systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Syndr. 2023;17(3):102729. doi:10.1016/j.dsx.2023.102729

  11. Karkon Varnosfaderani S, Hashem-Dabaghian F, Amin G, et al. Efficacy and safety of Amla (Phyllanthus emblica L.) in non-erosive reflux disease: a double-blind, randomized, placebo-controlled clinical trial. J Integr Med. 2018;16(2):126-131. doi:10.1016/j.joim.2018.02.008

  12. Ng QX, Loke W, Foo NX, et al. A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction. Phytother Res. 2020;34(3):583-590. doi:10.1002/ptr.6552

  13. Lopresti AL, Drummond PD, Smith SJ. A randomized, double-blind, placebo-controlled, crossover study examining the hormonal and vitality effects of ashwagandha (Withania somnifera) in aging, overweight malesAm J Mens Health. 2019;13(2):1557988319835985. doi:10.1177/1557988319835985

  14. Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol. 2014;151(1):528-535. doi:10.1016/j.jep.2013.11.008

  15. Brimson JM, Brimson S, Prasanth MI, et al. The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical dataScientific Reports. 2021;11(596). doi: 10.1038/s41598-020-80045-2

  16. Fatemeh Y, Siassi F, Rahimi A, et al. The effect of cardamom supplementation on serum lipids, glycemic indices and blood pressure in overweight and obese pre-diabetic women: a randomized controlled trial. J Diabetes Metab Disord. 2017;16:40. doi:10.1186/s40200-017-0320-8

  17. Aghasi M, Koohdani F, Qorbani M, et al. Beneficial effects of green cardamom on serum SIRT1, glycemic indices and triglyceride levels in patients with type 2 diabetes mellitus: a randomized double-blind placebo controlled clinical trial. J Sci Food Agric. 2019;99(8):3933-3940. doi:10.1002/jsfa.9617

  18. Khorasani F, Aryan H, Sobhi A, et al. A systematic review of the efficacy of alternative medicine in the treatment of nausea and vomiting of pregnancy. J Obstet Gynaecol. 2020;40(1):10-19. doi:10.1080/01443615.2019.1587392

  19. Nameni G, Moradi Y, Zaroudi M, Jamshidi S. Effect of cardamom supplementation on a number of metabolic factors: a systematic review and meta-analysisDiabetes Metab Syndr. 2022;16(6):102523. doi:10.1016/j.dsx.2022.102523

  20. Izadi B, Joulaei H, Lankarani KB, et al. The effect of green cardamom on blood pressure and inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized clinical trials. Phytother Res. 2023;37(2):679-688. doi:10.1002/ptr.7648

  21. Kunnumakkara AB, Banik K, Bordoloi D, et al. Googling the Guggul (Commiphora and Boswellia) for prevention of chronic diseases. Front Pharmacol. 2018;9:686. doi:10.3389/fphar.2018.00686

  22. Xiong XJ, Wang PQ, Li SJ, Li XK, Zhang YQ, Wang J. Garlic for hypertension: a systematic review and meta-analysis of randomized controlled trials. Phytomedicine. 2015;22(3):352-361. doi:10.1016/j.phymed.2014.12.013

  23. Hou LQ, Liu YH, Zhang YY. Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr. 2015;24(4):575-582. doi:10.6133/apjcn.2015.24.4.15

  24. De Greef D, Barton EM, Sandberg EN, et al. Anticancer potential of garlic and its bioactive constituents: a systematic and comprehensive review. Semin Cancer Biol. 2021;73:219-264. doi:10.1016/j.semcancer.2020.11.020

  25. Verma DK, G K, Kumar P, El-Shazly M. Unmasking the many faces of Giloy (Tinospora cordifolia L.): a fresh look on its phytochemical and medicinal propertiesCurr Pharm Des. 2021;27(22):2571-2581. doi:10.2174/1381612826666200625111530

  26. Kataria S, Sharma P, Ram JP, et al. A pilot clinical study of an add-on Ayurvedic formulation containing Tinospora cordifolia and Piper longum in mild to moderate COVID-19J Ayurveda Integr Med. 2022;13(2):100454. doi:10.1016/j.jaim.2021.05.008

  27. Patle D, Vyas M, Khatik GL. A review on natural products and herbs used in the management of diabetes. Curr Diabetes Rev. 2021;17(2):186-197. doi:10.2174/1573399816666200408090058

  28. Mittal A, Dabur R. Detection of new human metabolic urinary markers in chronic alcoholism and their reversal by aqueous extract of Tinospora cordifolia stem. Alcohol Alcohol. 2015;50(3):271-281. doi:10.1093/alcalc/agv012

  29. Patel SM, Nagulapalli Venkata KC, Bhattacharyya P, Sethi G, Bishayee A. Potential of neem (Azadirachta indica L.) for prevention and treatment of oncologic diseases. Semin Cancer Biol. 2016;40-41:100-115. doi:10.1016/j.semcancer.2016.03.002

  30. Iman M, Taheri M, Bahari Z. The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. J Complement Integr Med. 2021;19(2):203-211. doi:10.1515/jcim-2021-0009

  31. Zuccotti E, Oliveri M, Girometta C, et al. Nutritional strategies for psoriasis: current scientific evidence in clinical trials. Eur Rev Med Pharmacol Sci. 2018;22(23):8537-8551. doi:10.26355/eurrev_201812_16554

  32. Patil SM, Shirahatti PS, V B CK, Ramu R, M N NP. Azadirachta indica A. Juss (neem) as a contraceptive: An evidence-based review on its pharmacological efficiency. Phytomedicine. 2021;88:153596. doi:10.1016/j.phymed.2021.153596

  33. Dhingra K, Vandana KL. Effectiveness of Azadirachta indica (neem) mouthrinse in plaque and gingivitis control: a systematic review. Int J Dent Hyg. 2017;15(1):4-15. doi:10.1111/idh.12191

  34. Majumdar S, Gupta S, Prajapati SK, Krishnamurthy S. Neuro-nutraceutical potential of Asparagus racemosus: A review. Neurochem Int. 2021;145:105013. doi:10.1016/j.neuint.2021.105013

  35. Pandey AK, Gupta A, Tiwari M, et al. Impact of stress on female reproductive health disorders: possible beneficial effects of shatavari (Asparagus racemosus). Biomed Pharmacother. 2018;103:46-49. doi:10.1016/j.biopha.2018.04.003

  36. Uddin MS, Al Mamun A, Kabir MT, et al. Nootropic and anti-alzheimer's actions of medicinal plants: molecular insight into therapeutic potential to alleviate Alzheimer's neuropathology. Mol Neurobiol. 2019;56(7):4925-4944. doi:10.1007/s12035-018-1420-2

  37. Adithya J, Nair B, Aishwarya TS, Nath LR. The plausible role of Indian traditional medicine in combating Corona Virus (SARS-CoV 2): a mini-review. Curr Pharm Biotechnol. 2021;22(7):906-919. doi:10.2174/1389201021666200807111359

  38. National Center for Complementary and Integrative Health. Turmeric.

  39. Vaughn AR, Branum A, Sivamani RK. Effects of turmeric (Curcuma longa) on skin health: a systematic review of the clinical evidencePhytother Res. 2016;30(8):1243-1264. doi:10.1002/ptr.5640

  40. Zeng L, Yu G, Hao W, Yang K, Chen H. The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis. Biosci Rep. 2021;41(6):BSR20210817. doi:10.1042/BSR20210817

  41. Zeng L, Yang T, Yang K, et al. Efficacy and safety of curcumin and Curcuma Longaextract in the treatment of arthritis: a systematic review and meta-analysis of randomized controlled trial. Front Immunol. 2022;13:891822. doi:10.3389/fimmu.2022.891822

  42. Fusar-Poli L, Vozza L, Gabbiadini A, et al. Curcumin for depression: a meta-analysis. Crit Rev Food Sci Nutr. 2020;60(15):2643-2653. doi:10.1080/10408398.2019.1653260

  43. Shanbhag VK. Triphala in prevention of dental caries and as an antimicrobial in oral cavity- a review. Infect Disord Drug Targets. 2015;15(2):89-97. doi:10.2174/1871526515666150513105009

  44. Peterson CT, Denniston K, Chopra D. Therapeutic uses of triphala in Ayurvedic medicine. J Altern Complement Med. 2017;23(8):607-614. doi:10.1089/acm.2017.0083

  45. Phimarn W, Sungthong B, Itabe H. Effects of triphala on lipid and glucose profiles and anthropometric parameters: a systematic review. J Evid Based Integr Med. 2021;26:2515690X211011038. doi:10.1177/2515690X211011038

  46. Roe AL, Venkataraman A. The safety and efficacy of botanicals with nootropic effects. Curr Neuropharmacol. 2021;19(9):1442-1467. doi:10.2174/1570159X19666210726150432

  47. Jamshidi N, Cohen MM. The clinical efficacy and safety of tulsi in humans: a systematic review of the literature. Evid Based Complement Alternat Med. 2017;2017:9217567. doi:10.1155/2017/9217567

  48. Gopukumar K, Thanawala S, Somepalli V, et al. Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Evid Based Complement Alternat Med. 2021;2021:8254344. doi:10.1155/2021/8254344

  49. Shokoohi R, Kianbakht S, Faramarzi M, et al. Effects of an herbal combination on glycemic control and lipid profile in diabetic women: a randomized, double-blind, placebo-controlled clinical trial. J Evid Based Complementary Altern Med. 2017;22(4):798-804. doi:10.1177/2156587217737683

  50. Zadhoush R, Alavi-Naeini A, Feizi A, Naghshineh E, Ghazvini MR. The effect of garlic (Allium sativum) supplementation on the lipid parameters and blood pressure levels in women with polycystic ovary syndrome: A randomized controlled trial. Phytother Res. 2021;35(11):6335-6342. doi:10.1002/ptr.7282

  51. Koriem KM. Review on pharmacological and toxicologyical effects of oleum azadirachti oil. Asian Pac J Trop Biomed. 2013;3(10):834-840. doi:10.1016/S2221-1691(13)60165-3

  52. O'Leary MF, Jackman SR, Sabou VR, et al. Shatavari supplementation in postmenopausal women improves handgrip strength and increases vastus lateralis myosin regulatory light chain phosphorylation but does not alter markers of bone turnoverNutrients. 2021;13(12):4282. doi:10.3390/nu13124282

  53. Daily JW, Yang M, Park S. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of joint arthritis: a systematic review and meta-analysis of randomized clinical trialsJ Med Food. 2016;19(8):717-729. doi:10.1089/jmf.2016.3705

  54. Akhbari M, Firooz A, Rahimi R, Shirzad M, Esmaealzadeh N, Shirbeigi L. The effect of an oral product containing Amla fruit (Phyllanthus emblica L.) on female androgenetic alopecia: a randomized controlled trial. J Ethnopharmacol. 2023;318(Pt A):116958. doi:10.1016/j.jep.2023.116958

  55. Tandon N, Yadav SS. Safety and clinical effectiveness of Withania Somnifera (Linn.) Dunal root in human ailments. J Ethnopharmacol. 2020;255:112768. doi:10.1016/j.jep.2020.112768

  56. Lubarska M, Hałasiński P, Hryhorowicz S, et al. Liver dangers of herbal products: a case report of Ashwagandha-induced liver injury. Int J Environ Res Public Health. 2023;20(5):3921. doi:10.3390/ijerph20053921

  57. Borrelli F, Capasso R, Izzo AA. Garlic (Allium sativum L.): adverse effects and drug interactions in humans. Mol Nutr Food Res. 2007;51(11):1386-1397. doi:10.1002/mnfr.200700072

  58. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-induced liver injury: a case Review. Cureus. 2023;15(5):e39793. doi:10.7759/cureus.39793

  59. Alzohairy MA. Therapeutics role of Azadirachta indica (Neem) and their active constituents in diseases prevention and treatment. Evid Based Complement Alternat Med. 2016;2016:7382506. doi:10.1155/2016/7382506

  60. Foong SC, Tan ML, Foong WC, Marasco LA, Ho JJ, Ong JH. Oral galactagogues (natural therapies or drugs) for increasing breast milk production in mothers of non-hospitalised term infants. Cochrane Database Syst Rev. 2020;5(5):CD011505. doi:10.1002/14651858.CD011505.pub2

  61. Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res. 2018;32(6):985-995. doi:10.1002/ptr.6054

  62. Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-585. doi:10.1016/j.phymed.2013.10.024

  63. National Institutes of Health: National Center for Complementary and Integrative Health. Ashwagandha.

  64. Ramasamy S, Kiew LV, Chung LY. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Molecules. 2014;19(2):2588-2601. Published 2014 Feb 24. doi:10.3390/molecules19022588

  65. Sabarathinam S, Rajappan Chandra SK, Thangavel Mahalingam V. CYP3A4 mediated pharmacokinetics drug interaction potential of Maha-Yogaraj Gugglu and E, Z guggulsterone. Sci Rep. 2021;11(1):715. doi:10.1038/s41598-020-80595-5

  66. Chen XW, Serag ES, Sneed KB, et al. Clinical herbal interactions with conventional drugs: from molecules to maladies. Curr Med Chem. 2011;18(31):4836-4850. doi:10.2174/092986711797535317

  67. Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and type 2 diabetes mellitus: prevention and treatment. Nutrients. 2019;11(8):1837. doi:10.3390/nu11081837

  68. Balali-Mood M, Naseri K, Tahergorabi Z, et al. Toxic mechanisms of five heavy metals: Mercury, lead, chromium, cadmium, and arsenic. Front Pharmacol. 2021;12:643972. doi:10.3389/fphar.2021.643972

  69. National Center for Complementary and Integrative Health. Ayurvedic medicine: in depth.

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By Megan Nunn, PharmD
Nunn is a community pharmacist in Tennessee with 12 years of experience in medication counseling and immunization.