The Health Benefits of Lion's Mane

Lion's mane (Hericium erinaceus) is a type of medicinal mushroom. Long used in traditional Chinese medicine, lion's mane is widely available in fresh, dried, and supplement form. Scientific research shows that lion's mane contains a number of health-promoting substances, including antioxidants and beta-glucan.

This article discusses the potential health benefits of lion's mane mushroom and when to consider talking to your doctor about whether it might be right for you.

Potential Health Benefits of Lion's Mane

Proponents claim that lion's mane mushroom can help with a variety of health problems, including:

• Alzheimer's disease
• Anxiety
• Depression
• High cholesterol
• Inflammation
• Parkinson's disease
• Ulcers

In addition, lion's mane is said to strengthen the immune system, stimulate digestion, and protect against cancer.

The limited research indicates that lion's mane may offer certain health benefits, including support for neuronal health. Here's a look at some key study findings:

Brain Function

Lion's mane may benefit older adults with mild cognitive impairment, according to a small study published in Phytotherapy Research in 2009. For the study, researchers assigned 30 older adults with mild cognitive impairment to take either lion's mane extract or a placebo every day for 16 weeks. In cognitive tests given at weeks eight, 12, and 16 of the study, members of the lion's mane group showed significantly greater improvements compared to members of the placebo group.

In a more recent study (published in Biomedical Research in 2011), scientists examined the effects of lion's mane on brain function in mice. Results revealed that lion's mane helped protect against memory problems caused by the buildup of amyloid beta (a substance that forms the brain plaques associated with Alzheimer's disease). Studies have also shown a possible neuroprotective effect against ischemic stroke.

Depression and Anxiety

Research to date suggests that lion's mane may help alleviate depression and anxiety. For example, a 2020 review of the literature called lion's mane "a potential alternative medicine for the treatment of depression."

Likewise, a 2021 research review detailed several studies that showed significant anti-anxiety effects. Lion's mane appears to offer "neuroprotective functions, cytotoxicity, anticarcinogenic, antidiabetic, antimicrobial, and herbicidal activities," as well.

Possible Side Effects of Lion's Mane

Little is known about the safety of long-term use and side effects of lion's mane supplements. However, there's some concern that lion's mane may aggravate symptoms in people with allergies and asthma. Therefore, it's important to consult your physician prior to using lion's mane or any other supplement, especially if you have a history of allergies, asthma, and/or any other medical condition.

How to Take Lion's Mane

Lion's mane hasn't been studied enough to establish standard dosages and preparation. General guidelines follow, but always heed your physician's specific advice regarding medicines and supplements.

Dosage

Lion's mane is commonly consumed in many Asian countries for medicinal and culinary purposes, but there are no consistent formulations or dosage recommendations. Follow the instructions on your package of lion's mane closely.

Lion's Mane Precautions and Interactions

Avoid using lion's mane mushroom products if you're pregnant. Not enough research has been done to determine if any dosage is safe during pregnancy.

If you take diabetes medications, be aware that Lion's mane mushroom can lower your blood glucose levels too much. Keep a close eye on your readings.

Likewise, taking lion's mane along with anticoagulant/antiplatelet drugs can cause blood clotting difficulties that can result in bleeding or bruising.

Some people are allergic to lion's mane. Seek medical help immediately if you notice throat swelling, breathing trouble, or other signs and symptoms after taking lion's mane.

What to Look For When Buying Lion's Mane

Watch out for products claiming proven health benefits in humans; the majority of research has been limited to animal studies. Some lion's mane supplements have been marketed with unsupported claims, such as the promotion of weight loss, brain health, and the prevention of heart disease.

For example, in 2019, the Food and Drug Administration (FDA) sent a warning letter to Pure Nootropics, LLC, for making unsubstantiated claims about a variety of their products, including for their lion's mane powder. The company was marketing the supplement as "great for brain injury recovery" and to "reduce symptoms of anxiety and depression." Since then, the company has removed these specific claims from their marketing but continue to claim that the product "supports overall cognitive health."

Where to Find Lion's Mane

Many big-box and specialty online and brick-and-mortar stores sell fresh, dried, and/or powdered lion's mane, as well as capsules, teas, and various forms of blends featuring the fungi. In nature, they tend to grow in logs, decaying wood, and tree wounds.